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Radiation Protection Dosimetry Advance Access published online on June 10, 2008
Radiation Protection Dosimetry, doi:10.1093/rpd/ncn171
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Published by Oxford University Press 2008. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

EXPOSURE TO LOW LEVEL GSM 935 MHZ RADIOFREQUENCY FIELDS DOES NOT INDUCE APOPTOSIS IN PROLIFERATING OR DIFFERENTIATED MURINE NEUROBLASTOMA CELLS

J. Moquet*, E. Ainsbury, S. Bouffler and D. Lloyd

Health Protection Agency, Radiation Protection Division, Chilton, Didcot, Oxon OX11 0RQ, UK

* Corresponding author: jayne.moquet{at}hpa.org.uk

Received March 13, 2008, amended May 1, 2008, accepted May 1, 2008

The aim of this study was to investigate whether radiofrequency (RF) fields characteristic of mobile phones at non-thermal levels can induce apoptosis in murine neuroblastoma (N2a) cells in both proliferating and differentiated states. Cells were exposed continuously for 24 h to one of the three 935-MHz RF signals: global system for mobile communication (GSM) basic, GSM talk and a continuous wave, unmodulated signal; all at a specific energy absorption rate of 2 W kg–1. The measured increase in temperature of the cells due to the RF fields was around 0.06°C. At a number of time points between 0 and 48 h post-exposure, the cells were assessed for apoptosis under a fluorescence microscope using three independent assays: Annexin V, caspase activation and in situ end-labelling. No statistically significant differences in apoptosis levels were observed between the exposed and sham-exposed cells using the three assays at any time point post-exposure. These data suggest that RF exposures, characteristic of GSM mobile phones, do not significantly affect the apoptosis levels in proliferating and differentiated murine neuroblastoma cell line N2a.


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