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Radiation Protection Dosimetry Advance Access published online on June 11, 2007
Radiation Protection Dosimetry, doi:10.1093/rpd/ncm260
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© The Author 2007. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

MODELLING OF BIOASSAY DATA FROM A Pu WOUND TREATED BY REPEATED DTPA PERFUSIONS: BIOKINETICS AND DOSIMETRIC APPROACHES

P. Fritsch1,*, L. Grappin2, A. M. Guillermin2, R. Fottorino3, M. Ruffin3 and A. Mièle2

1 Laboratoire de Radiotoxicologie, SRCA/DRR/DSV/CEA, BP 12, 91680 Bruyères le Châtel, France
2 Service médical du travail, CEA Cadarache, 13108 Saint Paul lez Durance, France
3 Laboratoire d'analyses de biologie médicale, CEA Cadarache, 13108 Saint Paul lez Durance, France

* Corresponding author: paul.fritsch{at}cea.fr

The aim of this study is to model plutonium (Pu) excretion from the analysis of a well-documented Pu wound case involving repeated diethylene-triamine-penta-acetic acid (DTPA) perfusions up to 390 d and monitoring up to 3109 d. Three modelling approaches were simultaneously applied involving: (1) release of soluble Pu from the wound, estimated with the ICRP66 dissolution model, (2) systemic behaviour of Pu by using ICRP67 model, but also two new models recently reported and (3) additional ‘Pu-DTPA’ compartments which transfer Pu directly to urinary compartment from blood, interstitial fluids and liver. The best fit of simulations to biological data was obtained by using the new Leggett's systemic model and assuming the presence of three DTPA compartments. Calculations have shown that DTPA treatments have contributed to a 3-fold reduction of the effective dose. Thus, reduction of doses associated with the DTPA treatments can be estimated by modelling which is useful to improve the efficacy of a DTPA treatment schedule based on a diminution of risk.


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