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Radiation Protection Dosimetry Advance Access published online on January 8, 2007
Radiation Protection Dosimetry, doi:10.1093/rpd/ncl545
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received August 16, 2006
Revised November 28, 2006
Accepted December 3, 2006

SCIENTIFIC AND TECHNICAL PAPER

RADIATION-INDUCED MICRONUCLEUS FREQUENCIES IN FEMALE PERIPHERAL BLOOD LYMPHOCYTES COLLECTED DURING THE FIRST AND SECOND HALF OF THE MENSTRUAL CYCLE

Marta Krol 1, Anna Lankoff 1, Iwona Buraczewska 2, Edyta Derezinska 1, and Andrzej Wojcik 3 *

1 Department of Radiobiology and Immunology, Institute of Biology, Swietokrzyska Academy, 25-406 Kielce, Poland
2 Department of Radiation Biology and Health Protection, Institute of Nuclear Chemistry and Technology, 03-195 Warszawa, Poland
3 Department of Radiobiology and Immunology, Institute of Biology, Swietokrzyska Academy, 25-406 Kielce, Poland; Department of Radiation Biology and Health Protection, Institute of Nuclear Chemistry and Technology, 03-195 Warszawa, Poland

* To whom correspondence should be addressed.
Andrzej Wojcik, E-mail: awojcik{at}pu.kielce.pl


  Abstract

Biological dosimetry relies on the assessment of dose in peripheral blood lymphocytes (PBL) of a victim. Variability in the individual radiosensitivity of PBL has an impact on the precision of dose estimate and radiation-induced micronuclei show a strong individual variability. A factor which can influence the radiosensitivity of PBL is the hormonal status of female donors, which shows a regular pattern during the menstrual cycle. The aim of the present investigation was to verify whether the position within the menstrual cycle has an impact on the level of micronuclei in PBL. Blood was collected from 19 donors during the first and second half of the menstrual cycle and exposed to 2 Gy. Although statistically significant differences between the MN frequencies in PBL collected during the different time points were observed in the case of some donors, no reproducible trend that could find application in biological dosimetry could be detected.


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