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Radiation Protection Dosimetry Advance Access published online on January 8, 2007
Radiation Protection Dosimetry, doi:10.1093/rpd/ncl493
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Micros 2005 Special Issue

KILLING OF TARGET CELLS DUE TO RADON PROGENY IN THE HUMAN LUNG

B. M. F. Lau 1, D. Nikezic 2, and K. N. Yu 1 *

1 Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong
2 Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong; Faculty of Science, University of Kragujevac R. Domanovic 12, 34000 Kragujevac, Serbia and Montenegro

* To whom correspondence should be addressed.
K. N. Yu, E-mail: peter.yu{at}cityu.edu.hk


  Abstract

The dose conversion coefficient (DCC) is used to assess the risk due to inhaled radon progeny in the human lung. The present work uses the microdosimetric approach and determines the linear energy transfer in the target cell nuclei. Killing of target cells was also taken into account through an effect-specific track length model. To focus on the relevant part of the absorbed dose in the cell nuclei, the absorbed dose, which causes cell-killing is discarded in the final calculations of the DCC. Following this approach, the calculated DCC has become 3.4 mSv WLM-1 which is very close to the epidemiologically derived value of ~4 mSv WLM-1.


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