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Radiation Protection Dosimetry Advance Access published online on January 8, 2007
Radiation Protection Dosimetry, doi:10.1093/rpd/ncl485
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Micros 2005 Special Issue

DEPENDENCE OF NANODOSIMETRIC SPECTRA ON THE SENSITIVE VOLUME LENGTH AND ION DRIFT IN AN ION-COUNTING NANODOSEMETER

S. Shchemelinin 1, G. Hilgers 2, E. Gargioni 2, B. Grosswendt 2 *, A. Breskin 1, and R. Chechik 1

1 Weizmann Institute of Science, 76100 Rehovot, Israel
2 Physikalisch-Technische Bundesanstalt, Bundesallee 100, 38116 Braunschweig, Germany

* To whom correspondence should be addressed.
B. Grosswendt, E-mail: Bernd.Grosswendt{at}ptb.de


  Abstract

Nanodosimetric spectra, measured in a well-defined ionisation sensitive volume of an ion-counting gaseous nanodosemeter, may have a valuable predictive value of radiation damage to DNA. In such devices, the distributions of radiation-induced ions are measured after their drift in gas. The sensitive-volume size, corresponding to a DNA segment length, can be tuned by selecting an appropriate time window for ion counting; the method's accuracy depends on the velocity distribution of the drifting ions. The results of ion-drift measurements in an ion-counting nanodosemeter were used for the precise calculation of its sensitive volume length. Monte Carlo simulations of nanodosimetric spectra, performed with the obtained data, are in good agreement with experimental data. The method's limitations, arising from the spread of drift velocities, are discussed.


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