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Radiation Protection Dosimetry Advance Access published online on January 17, 2007
Radiation Protection Dosimetry, doi:10.1093/rpd/ncl476
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Micros 2005 Special Issue

ENHANCEMENT OF CHROMOSOMAL ABERRATIONS IN TUMOR CELLS WITH A NON-LABELED CU-PTSM AND IRRADIATION WITH CU K-SHELL MONOCHROMATIC X RAYS

Kaoru Takakura 1 *, Satoshi Yaguchi 1, Yuichi Kanansugi 1, Katsumi Kobayashi 2, Ryuichi Okayasu 3, and Yasuhisa Fujibayashi 4

1 Physics Department, Division of Natural Sciences, International Christian University, Mitaka-shi, Tokyo 181-8585, Japan
2 Institute of Material Science, High Energy Accelerator Organization, Tsukuba-shi, Ibaraki 305-0801, Japan
3 Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba-shi, Chiba 263-8555, Japan
4 Biomedical Imaging Research Center, Fukui University, Matsuoka, Fukui 910-1193, Japan

* To whom correspondence should be addressed.
Kaoru Takakura, E-mail: kaoru{at}icu.ac.jp


  Abstract

This study aims to clarify the enhancement effect on chromosomal aberrations via selective energy absorption by Cu atoms in cultured bone cancer cells with non-labelled Cu-pyruvaldehyde-bis(N4-methylsemicarbazone) (Cu-PTSM) and monochromatic X rays. The X rays having the energy of the Cu K-shell absorption edge arising from synchrotron radiation (KEK-PF) was used as radiation source. Cu-PTSM labelled with copper radionuclides has been developed for medical imaging using positron emission tomography (PET). Evidence clearly showed that the absorption of X rays in the Cu K-shell caused this enhancement. After cells were treated with 1000 nM Cu-PTSM, the enhancement ratio of the initial yield of isochromatid breaks caused by CuK-H X-ray irradiation to that by 200 kVp X rays was ~2.8. About 5.6 times of the remaining isochromatid breaks were observed at 4 h in Cu-PTSM treated samples irradiated with CuK-H X rays comparing to that with 200 kVp X rays. In this study, uniqueness in physical property such as Cu atom K-shell ionisation was applied for the enhancement of biological effects in cancer cells.


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