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Radiation Protection Dosimetry Advance Access published online on November 28, 2006
Radiation Protection Dosimetry, doi:10.1093/rpd/ncl430
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Micros 2005 Special Issue

KEEPING UP WITH THE NEIGHBOURS--MEASURING THE BYSTANDER RESPONSE

E. L. Pyke 1 *, D. L. Stevens 1, and M. A. Hill 1

1 MRC Radiation & Genome Instability Unit, Harwell, Oxfordshire OX11 0RD, UK

* To whom correspondence should be addressed.
E. L. Pyke, E-mail: e.pyke{at}har.mrc.ac.uk


  Abstract

Ionising radiation can induce responses within non-exposed neighbouring (bystander) cells, which potentially have important implications on the estimates of risk at environmentally relevant doses. Using human skin fibroblasts (AG1522), a range of methods were used to investigate the nature of the signal(s) arising from the exposed cells. The signal(s) can be transmitted by direct cell-cell communication (investigated by using partial dish irradiations) or by medium-borne factors (a co-culture system where two monolayers share the same medium but only one monolayer is exposed to ionising radiation). CDKN1A was found to be up-regulated in both directly exposed and non-exposed cells. The data suggest that direct cell-cell communication dominates for these confluent cells, with medium-borne factors also contributing.


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