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Radiation Protection Dosimetry Advance Access published online on December 4, 2006
Radiation Protection Dosimetry, doi:10.1093/rpd/ncl428
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Micros 2005 Special Issue

ALPHA-HIT, CELLULAR DOSE, CELL TRANSFORMATION AND INACTIVATION PROBABILITY DISTRIBUTIONS OF RADON PROGENIES IN THE BRONCHIAL EPITHELIUM

István Szoke 1 *, Imre Balásházy 2, Árpád Farkas 1, Werner Hofmann 3, Réka Szoke 2, Hatim Fakir 3, and Erika Kis 4

1 KFKI Atomic Energy Research Institute, 1525 Budapest, P.O. Box 49, Hungary; University of Salzburg, Hellbrunner Strasse 34, 5020 Salzburg, Austria
2 KFKI Atomic Energy Research Institute, 1525 Budapest, P.O. Box 49, Hungary
3 University of Salzburg, Hellbrunner Strasse 34, 5020 Salzburg, Austria
4 Babes-Bolyai University, Clinicilor 5-7, 400006 Cluj-Napoca, Romania

* To whom correspondence should be addressed.
István Szoke, E-mail: szoke{at}sunserv.kfki.hu


  Abstract

A fluid dynamics based model has been used to determine the deposition patterns of inhaled radon daughters in a realistic approach of the bronchial airway geometry. The interaction of the emitted alpha particles with epithelial cells has been analyzed by applying a complex hit probability model (Bronchial Alpha Hit Model). The biological response of the hit cells has been calculated by the Probability-Per-Unit-Track-Length Model which relates the probability of a specific biological effect to the track length of alpha particles as a function of the particles' linear energy transfer. The models mentioned above form a complex lung-radon interaction description. The calculations indicate that compared to the average values the transformation and cell killing probabilities are higher at bronchial carinal ridges. In addition, a considerable number of cells possessing a not negligible transformation and cell killing probabilities can also be found in the outer sides of the central zone.


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