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Radiation Protection Dosimetry Advance Access published online on June 14, 2005
Radiation Protection Dosimetry, doi:10.1093/rpd/nci313
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© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received March 29, 2005
Revised May 11, 2005
Accepted May 22, 2005

SCIENTIFIC NOTE

SENSITIVITY VARIATION OF DOPED FRICKE GEL IRRADIATED WITH MONOCHROMATIC SYNCHROTRON X RAYS BETWEEN 33.5 AND 80 keV

Stéphanie Corde 1*, Jean-François Adam 1, Marie-Claude Biston 1, Aurélie Joubert 1, Anne-Marie Charvet 1, François Estève 2, Jean-François Le Bas 2, Hélène Elleaume 1, and Jacques Balosso 3

1 INSERM-U647 Rayonnement synchrotron et recherche médicale and ID17 Biomedical Beamline of the European Synchrotron Radiation Facility, 6 rue Jules Horowitz, BP 220, F-38043 Grenoble Cedex, France
2 INSERM-U647 Rayonnement synchrotron et recherche médicale and ID17 Biomedical Beamline of the European Synchrotron Radiation Facility, 6 rue Jules Horowitz, BP 220, F-38043 Grenoble Cedex, France; Unité IRM, Centre Hospitalier Régional Universitaire, Grenoble, France
3 INSERM-U647 Rayonnement synchrotron et recherche médicale and ID17 Biomedical Beamline of the European Synchrotron Radiation Facility, 6 rue Jules Horowitz, BP 220, F-38043 Grenoble Cedex, France; Service de radiothérapie, Centre Hospitalier Régional Universitaire, Grenoble, France

* To whom correspondence should be addressed.
Stéphanie Corde, E-mail: stephanie_corde{at}yahoo.fr


  Abstract

An experimental binary radiotherapy proposes the concomitant use of a high-Z compound and synchrotron X rays for enhancing radiation dose selectively in tumours by a photoelectric effect. This study aimed at measuring the resulting dose enhancement in irradiated material. A doped Fricke gel dosemeter model was manufactured with 10 mg ml-1 of iodine (Telebrix) or barium (Micropaque). Samples were irradiated with a monochromatic synchrotron beam at 33.5, 50, 65 and 80 keV. The ensuing enhancement of the sensitivity of the dosemeter was derived from the nuclear magnetic resonance relaxation rates measured at different X-ray doses. Our results demonstrate (1) the preservation of a linear relationship between relaxation rates and X-ray doses for dosemeters doped with high-Z atoms and (2) a clear energy-dependent sensitivity enhancement for barium-doped Fricke gels. This enhancement was neither reproducible with iodinated compounds nor clearly related to the expected dose enhancement factor. However 1% barium sulphate in the gel could significantly improve the gel's response when it was irradiated by low-energy X rays.


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