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Radiation Protection Dosimetry Advance Access published online on October 5, 2004
Radiation Protection Dosimetry, doi:10.1093/rpd/nch405
Copyright © 2004 Oxford University Press.
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Received June 7, 2004
Revised July 26, 2004
Accepted September 4, 2004

SCIENTIFIC AND TECHNICAL PAPER

LONG-TERM ACCUMULATION OF URANIUM IN BONES OF WISTAR RATS AS A FUNCTION OF INTAKE DOSAGES

J. D. T. Arruda-Neto 1*, M. V. Manso Guevara 2, G. P. Nogueira 3, M. Saiki 4, A. C. Cestari 5, K. Shtejer 6, A. Deppman 2, J. W. Pereira Filho 2, F. Garcia 7, L. P. Geraldo 8, A. N. Gouveia 9, F. Guzmán 10, J. Mesa 2, O. Rodriguez 11, R. Semmler 4, and V. R. Vanin 2

1 Instituto de Física, Universidade de São Paulo, 05315-970, São Paulo, Brasil; Universidade de Santo Amaro/UNISA, 04829-300, São Paulo, Brasil
2 Instituto de Física, Universidade de São Paulo, 05315-970, São Paulo, Brasil
3 Faculdade de Medicina Veterinária/UNESP, 16050-680, Araçatuba, SP, Brasil
4 Instituto de Pesquisas Energéticas e Nucleares/IPEN, 05508-900, São Paulo, Brasil
5 Universidade de Santo Amaro/UNISA, 04829-300, São Paulo, Brasil
6 Centro de Estudios Aplicados al Desarrollo Nuclear, PO Box 6122, Playa, Havana, Cuba
7 Universidade Estadual de Santa Cruz, 45650-000, Ilhéus, Bahia, Brasil
8 Instituto de Pesquisas Energéticas e Nucleares/IPEN, 05508-900, São Paulo, Brasil; Universidade Católica de Santos/UNISANTOS, 11065-420, Santos, SP, Brasil
9 Instituto de Física, Universidade de São Paulo, 05315-970, São Paulo, Brasil; Instituto de Ciências Biomédicas, Universidade de São Paulo, 05508-900, SP, Brasil
10 Instituto Superior de Ciencia y Tecnologías Nucleares, 10600, Plaza, Havana, Cuba
11 Instituto de Física, Universidade de São Paulo, 05315-970, São Paulo, Brasil; Instituto Superior de Ciencia y Tecnologías Nucleares, 10600, Plaza, Havana, Cuba

* To whom correspondence should be addressed. E-mail: arruda{at}usp.br.


  Abstract

Groups of Wistar rats were fed with ration doped with uranyl nitrate at concentration A ranging from 0.5 to 100 ppm, starting after the weaning period and lasting until the postpuberty period when the animals were sacrificed. Uranium in the ashes of bones was determined by neutron activation analysis. It was found that the uranium concentration in the bones, as a function of A, exhibits a change in its slope at ~20 ppm--a probable consequence of the malfunctioning of kidneys. The uranium transfer coefficient was obtained and an analytical expression was fitted into the data, thus allowing extrapolation down to low doses. Internal and localized doses were calculated. Absorbed doses exceeded the critical dose, even for the lowest uranium dosage.


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