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Radiation Protection Dosimetry Advance Access originally published online on October 15, 2008
Radiation Protection Dosimetry 2008 132(2):232-240; doi:10.1093/rpd/ncn265
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© The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

The UK Childhood Cancer Study: maternal occupational exposures and childhood leukaemia and lymphoma

Patricia A. McKinney1,*, Olaide Y. Raji1, Martie van Tongeren2 and Richard G. Feltbower1

1 Paediatric Epidemiology Group, Centre for Epidemiology and Biostatistics, Room 8.49J, Level 8, Worsley Building, University of Leeds, Clarendon Way, Leeds LS2 9JT, UK
2 Institute of Occupational Medicine, Research Avenue North, Riccarton, Edinburgh EH14 4AP, UK

* Corresponding author: p.a.mckinney{at}leeds.ac.uk

Risks of childhood leukaemia and lymphoma were investigated for specific work-related exposures of mothers in the UK Childhood Cancer Study. Interviews with parents of 1881 leukaemia and lymphoma cases (0–14 years) and 3742 controls collected job histories recording exposure to eight specific agents. Exposure was (1) self-reported and (2) reviewed, based mainly on exposure probability and exposure level. Completeness, consistency and sufficiency evaluated data quality. Of all job exposures which were self-reported as exposed, 33% cases and 34% controls remained classified as exposed after review, with the remainder designated as partially exposed or unexposed. No review of underreporting of exposure was made. Data quality was ‘good’ for 26% of cases and 24% of controls. For self-reported exposure, significant risks of acute lymphoblastic leukaemia (ALL) were observed for solvents and petrol in all time windows. For reviewed exposure, solvents remained significant for ALL during pregnancy and postnatally. Restricting analyses to good-quality information removed all significant results. Refinement of exposure assessment revealed misclassification of self-reported exposures and data quality influenced risk assessment. Maternal exposure to solvents should further be investigated. These findings must invoke caution in the interpretation of risks reliant on self-reported occupational data.


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