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Radiation Protection Dosimetry Advance Access originally published online on March 12, 2008
Radiation Protection Dosimetry 2008 130(4):499-502; doi:10.1093/rpd/ncn068
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© The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Age-dependent potassium iodide effect on the thyroid irradiation by 131I and 133I in the nuclear emergency

M. Jang1,*, H. K. Kim1, C. W. Choi1 and C. S. Kang2

1 National Radiation Emergency Medical Center, Korea Institute of Radiological and Medical Science, Seoul, Korea
2 Department of Nuclear Engineering, Seoul National University, Seoul, Korea

* Corresponding author: mjang{at}kirams.re.kr

Received November 5, 2007, amended January 7, 2008, accepted February 6, 2008

The initial near-field exposure is primarily through inhalation in a nuclear emergency and the dominant contribution to the effective inhalation dose comes from radioiodine. Thyroid blockade by oral potassium iodide (KI) is efficient and practical for public in the nuclear emergency. Age-dependent radioprotective effect of KI on the thyroid irradiation by 131I and 133I has been derived using the simplified compartment model of iodine metabolism and WinSAAM program. Administration of KI within 2 h after 131I and 133I intake can block thyroid uptake significantly, yielding protective effect of 78.9% and 74.3%, respectively, for 131I and 133I for adults. The mean absorbed doses decrease with age, while protective effects of KI are similar for all age groups.


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