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Radiation Protection Dosimetry Advance Access originally published online on March 5, 2008
Radiation Protection Dosimetry 2008 129(1-3):13-21; doi:10.1093/rpd/ncn043
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© The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Radiation detector developments in medical applications: inorganic scintillators in positron emission tomography

Carel W. E. van Eijk*

Radiation Detection and Matter, R3, Faculty of Applied Sciences, Delft University of Technology, Mekelweg 15, 2629 JB Delft, The Netherlands

* Corresponding author: c.w.e.vaneijk{at}tudelft.nl

In recent years, a number of new gamma-ray scintillators are commercially available. These scintillators are either derived from known scintillators, e.g. Lu1-xYxAlO3: Ce (LuYAP) from LuAlO3:Ce and Lu2(1-x)Y2xSiO5:Ce (LYSO) from Lu2SiO5:Ce or are the result of new discoveries, e.g. LaCl3:Ce and LaBr3:Ce. The first two materials are primarily of interest because of the relatively high detection efficiency and fast response; LYSO has found application in time-of-flight (TOF) positron-emission tomography (TOF PET) and the LuYAP–LYSO combination is used in small-animal PET. The halide scintillators have an excellent energy resolution of ~3% at 662 keV and they have a relatively high light yield. LaBr3:Ce is being studied for application in TOF PET. At the same time, the search for and research on new scintillator materials are going on. For example, LuI3:Ce is a new material with a very high light yield (~90 000 photons MeV–1). Other examples of new materials are (C6H13NH3)2PbI4 and (C3H7NH3)2PbBr4, organic–inorganic hybrid compounds, of which the former has a very fast sub-nanosecond response. The new scintillators show great promise for new developments in medical applications, in particular, for PET systems.


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