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Radiation Protection Dosimetry Advance Access originally published online on June 11, 2007
Radiation Protection Dosimetry 2007 127(1-4):472-476; doi:10.1093/rpd/ncm300
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© The Author 2007. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Decorporation of plutonium by pulmonary administration of Ca-DTPA dry powder: a study in rat after lung contamination with different plutonium forms

A. L. Sérandour1,*, N. Tsapis2, C. Gervelas2, G. Grillon1, M. Fréchou1, J. R. Deverre3, H. Bénech4, E. Fattal2, P. Fritsch1 and J. L. Poncy1

1 CEA/DSV/DRR, Laboratoire de Radiotoxicologie, BP 12, 91680 Bruyères-Le-Châtel, France
2 Université Paris-Sud 11 CNRS, UMR 8612, Physico-chimie-Pharmacotechnie-Biopharmacie, 92296 Châtenay-Malabry, France
3 CEA/DSV/DRM, Service Hospitalier Frédéric Joliot, 91401 Orsay, France
4 CEA/DSV/DRM, Service de Pharmacologie et d'Immunologie, 91191, Gif-sur-Yvette, France

* Corresponding author: anne-laure.serandour{at}cea.fr

This study evaluates the decorporation efficacy of a pulmonary administration of a new Ca-DTPA (diethylenetriaminepentaacetic acid) dry powder (18 µmol kg–1 of body mass) after pulmonary contamination of rats with different Pu compounds. After inhalation of PuO2, a delayed intratracheal administration of DTPA cannot reduce significantly the retention of Pu in the lungs but limits its transfer in liver and skeleton. After pulmonary contamination by Pu nitrate, early insufflation of the DTPA powder appears twice as more efficient than an i.v injection of DTPA (30 µmol kg–1) to reduce Pu retention in the lungs and is as effective as i.v. injection to limit the extrapulmonary deposit. In contrast, a delayed administration of DTPA cannot reduce the lung or extrapulmonary retention. In conclusion, the improvement of aerodynamic properties of DTPA powder leads to an increase of DTPA amount deposited in the lungs and enhances the body decorporation.


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