Radiation Protection Dosimetry Advance Access originally published online on January 12, 2007
Radiation Protection Dosimetry 2007 124(2):155-163; doi:10.1093/rpd/ncl544
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Statistical modelling of Poisson/log–normal data
Los Alamos National Laboratory MS-G761 Los Alamos, NM 87545, USA
* Corresponding author: guthrie{at}lanl.gov
Received June 23, 2006, amended November 27, 2006, accepted December 3, 2006
In statistical data fitting, self consistency is checked by examining the closeness of the quantity
2/NDF to 1, where
2 is the sum of squares of data minus fit divided by standard deviation, and NDF is the number of data minus the number of fit parameters. In order to calculate
2 one needs an expression for the standard deviation. In this note several alternative expressions for the standard deviation of data distributed according to a Poisson/log–normal distribution are proposed and evaluated by Monte Carlo simulation. Two preferred alternatives are identified. The use of replicate data to obtain uncertainty is problematic for a small number of replicates. A method to correct this problem is proposed. The log–normal approximation is good for sufficiently positive data. A modification of the log–normal approximation is proposed, which allows it to be used to test the hypothesis that the true value is zero.
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