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Radiation Protection Dosimetry Advance Access originally published online on September 5, 2006
Radiation Protection Dosimetry 2007 123(2):241-245; doi:10.1093/rpd/ncl109
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

SCIENTIFIC NOTES

Biodosimetry using chromosome aberrations in human lymphocytes

S. Senthamizhchelvan1, G. S. Pant1,*, G. K. Rath2, P. K. Julka2, O. Nair2, R. C. Joshi2, A. Malhotra1 and R. M. Pandey3

1 Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110 029, India
2 Department of Radiotherapy, All India Institute of Medical Sciences, New Delhi 110 029, India
3 Department of Biostatistics, All India Institute of Medical Sciences, New Delhi 110 029, India

* Corresponding author: gspant{at}rediffmail.com

Received March 29, 2006, amended July 27, 2006, accepted July 30, 2006


  Abstract

In vitro dose–response calibration curves for 60Co gamma rays have been established for unstable chromosome aberrations in human peripheral blood lymphocytes. The observed dose–response data were fitted to a linear quadratic model. The calibration curve parameters were used to estimate the equivalent whole-body dose and dose to the irradiated region in partial body irradiation of cancer patients. The derived partial body doses and fractions of lymphocytes irradiated were in agreement with those estimated from the radiotherapy regimes.


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