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Radiation Protection Dosimetry Advance Access originally published online on December 4, 2006
Radiation Protection Dosimetry 2006 122(1-4):540-542; doi:10.1093/rpd/ncl428
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Alpha-hit, cellular dose, cell transformation and inactivation probability distributions of radon progenies in the bronchial epithelium

István Szoke1,2, Imre Balásházy1, Árpád Farkas1,2, Werner Hofmann2, Réka Szoke1, Hatim Fakir2 and Erika Kis3

1 KFKI Atomic Energy Research Institute, 1525 Budapest, P.O. box 49, Hungary
2 University of Salzburg, Hellbrunner Str. 34, 5020 Salzburg, Austria
3 Babes-Bolyai University, Clinicilor 5-7, 400006 Cluj-Napoca, Romania

* Corresponding author: E-mail: szoke{at}sunserv.kfki.hu


  Abstract

A fluid dynamics based model has been used to determine the deposition patterns of inhaled radon daughters in a realistic approach of the bronchial airway geometry. The interaction of the emitted alpha particles with epithelial cells has been analyzed by applying a complex hit probability model (Bronchial Alpha Hit Model). The biological response of the hit cells has been calculated by the Probability-Per-Unit-Track-Length Model, which relates the probability of a specific biological effect to the track length of alpha particles as a function of the particles' LET. The models mentioned above form a complex lung–radon interaction description. The calculations indicate that compared to the average values the transformation and cell killing probabilities are higher at bronchial carinal ridges. In addition, a considerable number of cells possessing a not negligible transformation and cell killing probabilities can also be found in the outer sides of the central zone.


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