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Radiation Protection Dosimetry Advance Access originally published online on December 8, 2006
Radiation Protection Dosimetry 2006 122(1-4):451-454; doi:10.1093/rpd/ncl515
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

First attempts at prediction of DNA strand-break yields using nanodosimetric data

G. Garty1,4,*, R. Schulte2, S. Shchemelinin1, B. Grosswendt3, C. Leloup1,5, G. Assaf1, A. Breskin1, R. Chechik1 and V. Bashkirov2

1 Department of Particle Physics, Weizmann Institute of Science, Rehovot, 76100, Israel
2 Department of Radiation Medicine, Loma Linda University Medical Center, Loma Linda, CA 92354, USA
3 Physikalisch-Technische Bundesanstalt (PTB), Braunschweig, D-38116, Germany
4 Present address: RARAF, Columbia University, P.O. Box 21, Irvington, NY 10533, USA
5 Present address: The Center for Radiological Research, Columbia University, New York, NY 10032, USA

* Corresponding author: gyg2101{at}columbia.edu


  Abstract

We present the first results of our attempts to correlate yields of ionisation clusters in a gas model of DNA and corresponding double-strand break (DSB) yields in irradiated plasmids, using a simple statistical model of DNA lesion formation. Based on the same statistical model, we also provide a comparison of simulated nanodosimetric data for electrons and published DSB yields obtained with the PARTRAC code.


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