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Radiation Protection Dosimetry Advance Access originally published online on December 13, 2006
Radiation Protection Dosimetry 2006 122(1-4):340-344; doi:10.1093/rpd/ncl513
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Mechanistic models of bone cancer induction by radium and plutonium in animals compared to humans

H. Bijwaard*

RIVM-National Institute for Public Health and the Environment, Laboratory for Radiation Research, Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The Netherlands

* Corresponding author: Harmen.Bijwaard{at}rivm.nl


  Abstract

Two-mutation carcinogenesis models of mice and rats injected with 239Pu and 226Ra have been derived extending previous modellings of beagle dogs injected with 239Pu and 226Ra and radium dial painters. In all cases statistically significant parameters could be derived fitting data from several research groups jointly. This also lead to similarly parametrised models for 239Pu and 226Ra for all species. For each data set not more than five free model parameters were needed to fit the data adequately. From the toxicity ratios of the animal models for 239Pu and 226Ra, together with the human model for 226Ra, an approximate model for the exposure of humans to 239Pu has been derived. Relative risk calculations with this approximate model are in good agreement with epidemiological findings for the plutonium-exposed Mayak workers. This promising result may indicate new possibilities for estimating risks for humans from animal experiments.


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