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Radiation Protection Dosimetry Advance Access originally published online on January 24, 2007
Radiation Protection Dosimetry 2006 122(1-4):271-274; doi:10.1093/rpd/ncl431
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Gamma ray-induced bystander effect in tumour glioblastoma cells: a specific study on cell survival, cytokine release and cytokine receptors

A. Facoetti1,2,*, F. Ballarini2,3, R. Cherubini4, S. Gerardi4, R. Nano1, A. Ottolenghi2,3, K. M. Prise5, K. R. Trott5 and C. Zilio4

1 Department of Animal Biology, University of Pavia, Piazza Botta 10, 27100 Pavia, Italy
2 National Institute of Nuclear Physics, Section of Pavia, Via Bassi 6, 27100 Pavia, Italy
3 Department of Nuclear and Theoretical Physics, University of Pavia, Via Bassi 6, 27100 Pavia, Italy
4 National Institute of Nuclear Physics, Laboratories of Legnaro, Viale Università 2, 35020 Legnaro (PD), Italy
5 Gray Cancer Institute, P.O. Box 100, Mount Vernon Hospital Northwood, Middlesex HA6 2JR, UK

*Corresponding author: facoetti{at}unipv.it


  Abstract

Recent experimental evidence has challenged the paradigm according to which radiation traversal through the nucleus of a cell is a prerequisite for producing genetic changes or biological responses. Thus, unexposed cells in the vicinity of directly irradiated cells or recipient cells of medium from irradiated cultures can also be affected. The aim of the present study was to evaluate, by means of the medium transfer technique, whether interleukin-8 and its receptor (CXCR1) may play a role in the bystander effect after gamma irradiation of T98G cells in vitro. In fact the cell specificity in inducing the bystander effect and in receiving the secreted signals that has been described suggests that not only the ability to release the cytokines but also the receptor profiles are likely to modulate the cell responses and the final outcome. The dose and time dependence of the cytokine release into the medium, quantified using an enzyme linked immunosorbent assay, showed that radiation causes alteration in the release of interleukin-8 from exposed cells in a dose-independent but time-dependent manner. The relative receptor expression was also affected in exposed and bystander cells.


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F. Ballarini, D. Alloni, A. Facoetti, A. Mairani, R. Nano, and A. Ottolenghi
Modelling radiation-induced bystander effect and cellular communication
Radiat Prot Dosimetry, December 1, 2006; 122(1-4): 244 - 251.
[Abstract] [Full Text] [PDF]


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