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Radiation Protection Dosimetry Advance Access originally published online on November 28, 2006
Radiation Protection Dosimetry 2006 122(1-4):266-270; doi:10.1093/rpd/ncl430
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Keeping up with the neighbours—measuring the bystander response

E. L. Pyke*, D. L. Stevens and M. A. Hill

MRC Radiation & Genome Instability Unit, Harwell, Oxfordshire OX11 0RD, UK

* Corresponding author: e.pyke{at}har.mrc.ac.uk


  Abstract

Ionising radiation can induce responses within non-exposed neighbouring (bystander) cells, which potentially have important implications on the estimates of risk at environmentally relevant doses. Using human skin fibroblasts (AG1522), a range of methods were used to investigate the nature of the signal(s) arising from the exposed cells. The signal(s) can be transmitted by direct cell–cell communication (investigated by using partial dish irradiations) or by medium-borne factors (a co-culture system where two monolayers share the same medium but only one monolayer is exposed to ionising radiation). CDKN1A was found to be up-regulated in both directly exposed and non-exposed cells. The data suggest that direct cell–cell communication dominates for these confluent cells, with medium-borne factors also contributing.


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