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Radiation Protection Dosimetry Advance Access originally published online on December 21, 2006
Radiation Protection Dosimetry 2006 122(1-4):136-140; doi:10.1093/rpd/ncl453
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Computer simulation of strand break yields in plasmid pBR322: DNA damage following 125I decay

S. Edel1, M. Terrissol1,*, A. Peudon1, E. Kümmerle2 and E. Pomplun2

1 CPAT, Bât. 3R2, Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 9, France
2 Geschäftsbereich Sicherheit und Strahlenschutz, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany

* Corresponding author: terrissol{at}cpat.ups-tlse.fr


  Abstract

This paper presents results of 125I effects on plasmid pBR322 in aqueous solution, simulating the complete transport of Auger and X rays up to the chemical phase. In addition to new sampling algorithms, new electronic cross sections are included. Simulations were carried out both with 125I, bound to plasmid, or free, in its vicinity. The influence of the hydroxyl radical scavenger dimethyl sulfoxyde (DMSO) has also been tested, underlying that, in naked DNA, double strand breaks (caused by the decay of bound 125I) are mainly due to direct hits. The calculated yields of relaxation events (RE) and linearization events (LE) show good agreement with experimental ones: when 125I is bound to the plasmid pBR322, 0.16 RE and 0.83 LE per decay (without DMSO) are then observed. Then, when 2 mol DMSO is added, RE and LE probabilities become 0.22 and 0.76. The very light differences with those from literature could arise from experimental conditions.


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