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Radiation Protection Dosimetry Advance Access originally published online on January 17, 2007
Radiation Protection Dosimetry 2006 122(1-4):110-112; doi:10.1093/rpd/ncl417
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Theoretical modelling of radiolytic damage of free DNA bases and within DNA macromolecule

Václav Stepán1,2 and Marie Davídková2,*

1 Faculty of Nuclear Sciences and Physical Engineering, Department of Dosimetry and Application of Ionizing Radiation, Czech Technical University, Brehová 7, Prague 1, 115 19, Czech Republic
2 Department of Radiation Dosimetry, Nuclear Physics Institute AS CR, Na Truhlárce 39/64, Prague 8, 180 86, Czech Republic,

* Corresponding author: davidkova{at}ujf.cas.cz


  Abstract

The base damages in living cell are the most frequent product of deleterious effect of ionizing radiation. Experimental yields of modified bases determined in free bases and in the double stranded DNA show significant differences in the yields of stable products of radiolytic attack. An attempt to explain these differences is made with the help of theoretical calculations. The relative probabilities of reactions of the most important radiolytic product, OH• radical, with individual nucleobases, nucleosides and short DNA oligomers are calculated and compared to available experimental yields of base damages.


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