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Radiation Protection Dosimetry Advance Access published online on April 4, 2009
Radiation Protection Dosimetry, doi:10.1093/rpd/ncp056
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© The Author 2009. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

ESTIMATING THE LUNG BURDEN FROM EXPOSURE TO AEROSOLS OF DEPLETED URANIUM

Marcelo Valdés*

Uranium Medical Research Center, Shawville, Quebec, Canada J0X 2Y0

* Corresponding author: mjvv{at}magma.ca

Received February 4, 2009, amended February 4, 2009, accepted March 10, 2009

Following exposure to aerosols of depleted uranium (DU), biological samples show the presence of a synthetic mixture of natural uranium and DU. By partitioning the uranium in the 24-h urine sample along the isotopic fractions of natural uranium and DU, one can study the kinetics of these subpopulations independently. A linear model is developed to estimate the lung burden of DU from measurements of DU in 24-h urine samples, years after inhalational exposure to aerosols of DU. This model takes into account the intracellular dissolution of the retained particles and the precipitation of a significant fraction of the dissolved DU as insoluble uranyl phosphates.

Key Words: depleted uranium • lung burden • inhalational exposure


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