Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Watkin, R.D.
Right arrow Articles by Tyrrell, R.M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Watkin, R.D.
Right arrow Articles by Tyrrell, R.M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Radiation Protection Dosimetry 91:85-88 (2000)
© 2000 Oxford University Press

Study of the Relationship Between Endogenous Protoporphyrin IX Concentration in Human Lymphoblastoid Cells and Inactivation by UVA Radiation

R.D. Watkin and R.M. Tyrrell

Intracellular content of the endogenous chromophore protoporphyrin IX (PPIX) can be modulated by administration of the haem precursor d-aminolevulinic acid (ALA). Exogenous addition of ALA effectively bypasses the rate limiting ALA synthesis step in the haem biosynthetic pathway leading to the accumulation of PPIX. The purpose of this study was to examine the relationship between PPIX concentration and the level of inactivation of cultured human lymphoblastoid cells in order to determine if the basal PPIX content of these cells determines the level of inactivation by UVA. From the relationship between inactivation rate constants at each PPIX concentration an estimate was made of the basal level of PPIX that would be necessary to mediate significant cell death by UVA radiation. It is concluded that the basal content of PPIX is insufficient to make a major contribution to the UVA inactivation of these lymphoblastoid cells.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.