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Radiation Protection Dosimetry 91:65-71 (2000)
© 2000 Oxford University Press

Sunlight and Vitamin D: The Bone and Cancer Connections

M.F. Holick (INVITED)

Vitamin D plays an essential role for calcium metabolism and bone health. It has been estimated that 90 to 95% of our vitamin D requirement comes from casual exposure to sunlight. There is a wide variety of factors that strongly influence the cutaneous production of vitamin D. These include melanin pigmentation, latitude, time of day, sunscreen use, and aging. There is an association with increased risk and mortality to breast, colon, and prostrate cancer. There is evidence that 25-hydroxyvitamin D, the major circulating form of vitamin D, is directly metabolised in prostate, breast, colon, and skin cells to its active form 1,25-dihydroxyvitamin D. 1,25-Dihydroxyvitamin D3 has the capacity to regulate cell proliferation and differentiation. Therefore, it may be that an increase in the cutaneous synthesis of vitamin D results in the increase in the production of 1,25(OH)2D in tissues not related to calcium metabolism that results in a decrease in malignancy.


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