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Radiation Protection Dosimetry 91:47-50 (2000)
© 2000 Oxford University Press

Ultraviolet Radiation Induced Apoptosis in Human Skin In Vivo

J.M. Sheehan and A.R. Young

Sunburn cells, having many characteristics of apoptotic cells, appear in human skin after exposure to UVB. Time-courses and dose responses for solar simulated radiation (SSR)-induced sunburn cells in human volunteers of skin type II have been determined. For the time-course, two groups of volunteers were exposed to two minimal erythema doses (MED) of SSR. Punch biopsies were obtained from Group 1 immediately, 3, 6, 12, 18 and 24 h after SSR exposure and Group 2 were biopsied immediately, 18, 24, 36, 48 and 72 h after exposure. For the dose-response (Group 3), biopsies were taken 24 h after SSR exposure to 0, 0.25, 0.5, 1, 2 and 3 MED. Sections were stained with H&E and also using TUNEL and analysed by light microscopy. Results show a dose-dependent appearance of SBC after SSR exposure. The time point for maximum SBC counts with both H&E staining and TUNEL staining lie between 24 and 36 h.


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