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Radiation Protection Dosimetry 82:175-192 (1999)
© 1999 Oxford University Press

DOSE210, A Semi-empirical Model for Prediction of Organ Distribution and Radiation Doses from Long Term Exposure to 210Pb and 210Po

P.L. Salmon, O.A. Bondarenko and D.L. Henshaw

The DOSE210 model is an internal dosimetric model for 210Pb and 210Po which is based on current ICRP generic models. It is constrained and validated by reference to up-to-date published biokinetic data for both nuclides. The model has been validated primarily in regard to the relation between levels of chronic lifetime intake and organ concentrations of 210Pb and 210Po. To this end some adjustments to current ICRP biokinetic parameters have been made. The most substantial changes have been made to bone surface biokinetics of 210Pb and 210Po to reflect recent experimental studies on the microdistribution and radioactive equilibrium of these nuclides in bone, as well as measurements in biopsied human red bone marrow. An important dosimetric prediction of DOSE210 is a substantially lower dose to skeletal tissues from internal 210Pb and 210Po than that predicted by the current ICRP model. The most significant dose component predicted from lifetime environmental exposure to 210Pb and 210Po is the alpha dose to liver and kidney in infancy. Recycling of historic intakes of 210Pb in the adult, principally from bone, is calculated to account for 22% of 210Pb present in the plasma.


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