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Radiation Protection Dosimetry 62:31-34 (1995)
© 1995 Oxford University Press

The Adaptive Repair Response in Tissues of Chronically Irradiated Mice

L.A. Fomenko, Ja.K. Kozhanowskaja and A.I. Gaziev

It is shown that the chronic pre-irradiation of mice at a very low dose rate (0.0013 Gy.h-1) with a wide range of adapting doses (0.12-2.54 Gy) activates the DNA repair, increases the DNA polymerase activity in different tissues and decreases the yield of chromosome damage in bone marrow of these mice subjected to additional acute irradiation. These data allow us to make the suggestion that in these animals adaptive repair response to the subsequent ionising radiation can be induced with a wide range of cumulative doses of chronic pre-irradiation at a very low dose rate.


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