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Radiation Protection Dosimetry 62:27-30 (1995)
© 1995 Oxford University Press

Stress and Radioresistance (Genetic Aspects)

N.M. Lyubaschevsky and E.B. Grigorkina

Inbred mice and randomly bred stock were exposed to long-term adrenaline and hypothermia stress effects for unification of their functional status, followed by acute total gamma irradiation by equal-effect doses (LD50/30). The significant reduction of lethality distribution in inbred mice after combined stress and radiation effects was observed. The spread of lethality in random bred stock was increased as compared to the control group. The post-irradiation mortality in experimental animals differed only slightly from the values in the control groups. Conclusions are drawn about the principal meaning of genotype in radiosensitivity, about the role of an organism's functional status in determination of death date and about the possible epigenetic structuralisation of linear mice by radioresistance.


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