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Radiation Protection Dosimetry 56:105-108 (1994)
© 1994 Oxford University Press

Cocarcinogenic Effect of Cytochrome P-450 1A1 Inducers for Epidermoid Lung Tumour Induction in Rats Previously Exposed to Radon

E. Douriez, P. Kermanac'h, P. Fritsch, M. Bisson, J.P. Morlier, G. Monchaux, M. Morin and P. Laurent

The aim of this work was to characterise the cocarcinogenic effect of CYP1A1 inducers in male Sprague-Dawley rats previously exposed to 1000 WLM radon. Three inducers were used: methylcholanthrene (MC), metabolised by CYP1A1 into strong mutagenic compounds; 5,6-benzoflavone (ßNF) metabolised into non-mutagenic compounds; and 2,3,7,8 tetrachlorobenzo-p-dioxin (TCDD) regarded as non-mutagenic and non-metabolised. These inducers were administered by six repeated intramuscular injections of 25, 25 and 0.0013 mg per kg respectively at 2-week intervals. Rats were studied 1 or 4 months after the end of the treatments. A cocarcinogenic effect was observed for each compound corresponding to specific occurrences of squamous cell carcinoma. Latency periods for about 100% tumour induction were about 100 days for MC and ßNF but increased to 200 days for TCDD. Biochemical studies have shown a similar global CYP1A1 induction for each treatment corresponding to about 40 times the control value. Immunohistolocalisation of CYP1A1 was confined to some bronchial cells in controls whereas it was clearly demonstrated after each chemical treatment in hyperplastic epithelial foci.


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