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Radiation Protection Dosimetry 32:245-252 (1990)
© 1990 Oxford University Press

Plutonium Content in Marrow and Mineralised Bone in an Occupationally Exposed Person

J.F. McInroy and R.L. Kathren

Organic and mineral components of bone from the vertebral bodies of an individual with occupational exposure to plutonium were separated by each of four techniques: (1) chemical separation with ethylenediamine, (2) mechanical separation by a stream of water, (3) mechanical separation by ultrasonic agitation, and (4) thermal separation by heating in an autoclave; all samples were subjected to radiochemical analysis for 239+240Pu. Nearly all of the total skeletal plutonium was associated with the mineral bone. Concentrations of plutonium in the organic fraction were only a few per cent of those in the mineralised bone. Approximately 3% of the total skeletal plutonium was estimated to be resident in the marrow, with the concentration in the red marrow 2-5 times greater than the concentration in the yellow marrow. This suggests that the dose to the mineralised portion of the bone and closely associated cells, including those of the periosteum and endosteum, may be an order of magnitude or more greater than the dose to the red marrow, resulting in a several fold greater risk from bone tumorigenesis than leukaemias when the relative risk per unit dose is factored in.


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R. L. Kathren
A review of contributions of human tissue studies to biokinetics, bioeffects and dosimetry of plutonium in man
Radiat Prot Dosimetry, July 1, 2004; 109(4): 399 - 407.
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