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Radiation Protection Dosimetry 2009 134(2):79-86; doi:10.1093/rpd/ncp085
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© The Author 2009. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Determination of human absorbed dose of 67GA-DTPA-ACTH based on distribution data in rats

Saeed Shanehsazzadeh1,*, Amir Reza Jalilian2, Hamid Reza Sadeghi3 and Mahmoud Allahverdi1

1 Department of Biomedical Physics and Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2 Nuclear Medicine Group, Agricultural, Medical and Industrial Research School (AMIRS-NSTRI) Karaj, Iran
3 Department of Biomedical Physics and Engineering, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran

* Corresponding author: shanehsazzadeh{at}razi.tums.ac.ir

Received October 18, 2008, amended April 14, 2009, accepted April 25, 2009

The absorbed radiation dose to human organs has been estimated, following intravenous administration of 67Ga-labelled adrenocorticotrophic hormone (ACTH) using distribution data from injected normal rats. Four rats were sacrificed at exact time intervals and the percentage of injected dose per gram of each organ was measured by direct counting from rat data. The Medical Internal Radiation Dose formulation was applied to extrapolate from rat to human and to project the absorbed radiation dose for various organs in a human. From rat data, it is estimated that a 185-MBq injection of 67Ga-diethylenetriaminepentaacetic acid-ACTH into a human might result in an estimated absorbed dose of 2.22 mGy to the whole body; the highest absorbed dose was in the bladder wall with 82.1 mGy and the organs that received the next highest doses were the lungs 31.8, liver 22.6 and spleen 8.72 mGy. These results suggest that it should be possible to perform early imaging of the lung anomalies.


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