Skip Navigation


Radiation Protection Dosimetry Advance Access originally published online on April 17, 2009
Radiation Protection Dosimetry 2009 134(1):49-54; doi:10.1093/rpd/ncp062
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
134/1/49    most recent
ncp062v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Chu, C.-H.
Right arrow Articles by Lin, U.-T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chu, C.-H.
Right arrow Articles by Lin, U.-T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Dosimetry study for β-radiation treatment of in-stent restenosis

Chien-Hau Chu1,2, Bor-Tsung Hsieh3, Ing-Jane Chen1, Wei-Li Chen2 and Uei-Tyng Lin4,*

1 Health Physics Division, Institute of Nuclear Energy Research, PO Box 3-10, Longtan 325, Taiwan, Republic of China
2 Faculty of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei 112, Taiwan, Republic of China
3 Institute of Radiological Science, Central Taiwan University of Science and Technology, Taichung 406, ROC
4 Institute of Radiological Sciences, Tzu Chi College of Technology, 880 Section 2, Chien-Kuo Road, Hualien 970, Taiwan, Republic of China

* Corresponding author: utlin{at}tccn.edu.tw

Received November 16, 2008, amended March 5, 2009, accepted March 25, 2009

Intravascular brachytherapy (IVBT) has been recognised as a treatment modality for reducing coronary restenosis after angioplasty and stent-implantation procedures. For the treatment of in-stent restenosis using beta-emitter 188Re, delivering adequate doses to the entire vessel wall is not possible without the potential of overdosing tissues. A method to measure the dose distribution, perturbation and percentage depth dose using plane-parallel and cylindrical tissue-equivalent phantoms has been developed. Good agreement was found between experimental results and Monte Carlo simulation performed using MCNP4C code. The dose given to the affected area in the vascular region for intravascular radiation treatment was 15–30 Gy. Dose inhomogeneity beyond the stent surface decreased significantly with increasing radial distance. In the region close to the stent outer surface (>0.5-mm radial distance), a dose reduction of 11–17% due to the stent was observed. However, the dose perturbations due to the physical properties of metallic stents were found to be significant in IVBT for in-stent restenosis by using measured dose profiles in phantoms. The method can provide accuracy in beta isotope in vivo dosimetry results for treatments involving short-range dose distributions and provide a relatively high-level spatial resolution for detection.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.