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Radiation Protection Dosimetry Advance Access originally published online on October 15, 2008
Radiation Protection Dosimetry 2008 132(2):182-190; doi:10.1093/rpd/ncn262
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© The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Epidemiological studies of leukaemia in children and young adults around nuclear facilities: a critical review

D. Laurier*, S. Jacob, M. O. Bernier, K. Leuraud, C. Metz, E. Samson and P. Laloi

Institute for Radiological Protection and Nuclear Safety, IRSN, DRPH/SRBE, BP17, F-92262 Fontenay-aux-Roses Cedex, France

* Corresponding author: dominique.laurier{at}irsn.fr

The existence of an increased risk of childhood leukaemia near nuclear installations is a recurrent issue. A review of the related epidemiological literature is presented here. Results for 198 nuclear sites throughout 10 countries were included in the review. In addition to local studies, 25 multi-site studies have been published for eight countries. A large variability was noticed in the quality of the data as well as in the definition of the study population and in the methods of analysis. Many studies present important limits that make the results difficult to interpret. The review confirms that some clusters of childhood leukaemia cases exist locally. However, results based on multi-site studies around nuclear installations do not indicate an increased risk globally. Many studies were launched to investigate possible origins of the observed clusters around specific sites, but up to now, none of the proposed hypotheses have explained them.


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D. Laurier, S. Jacob, and P. Laloi
Letter to the Editor
Radiat Prot Dosimetry, November 5, 2009; (2009) ncp247v1.
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