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Radiation Protection Dosimetry Advance Access originally published online on March 12, 2008
Radiation Protection Dosimetry 2008 130(2):213-223; doi:10.1093/rpd/ncm498
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© The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Normalisation of spot urine samples to 24-h collection for assessment of exposure to uranium

R. Marco, E. Katorza, R. Gonen, U. German, A. Tshuva, O. Pelled, O. Paz-Tal, A. Adout and Z. Karpas*

Nuclear Research Center Negev, PO Box 9001, Beer-Sheva 84190, Israel

* Corresponding author: karpas4{at}netvision.net.il

Received September 19, 2007, amended November 25, 2007, accepted December 13, 2007

For dose assessment of workers at Nuclear Research Center Negev exposed to natural uranium, spot urine samples are analysed and the results are normalised to 24-h urine excretion based on ‘standard’ man urine volume of 1.6 l d–1. In the present work, the urine volume, uranium level and creatinine concentration were determined in two or three 24-h urine collections from 133 male workers (319 samples) and 33 female workers (88 samples). Three volunteers provided urine spot samples from each voiding during a 24-h period and a good correlation was found between the relative level of creatinine and uranium in spot samples collected from the same individual. The results show that normalisation of uranium concentration to creatinine in a spot sample represents the 24-h content of uranium better than normalisation to the standard volume and may be used to reduce the uncertainty of dose assessment based on spot samples.


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