Skip Navigation


Radiation Protection Dosimetry Advance Access originally published online on October 19, 2007
Radiation Protection Dosimetry 2008 129(4):372-380; doi:10.1093/rpd/ncm444
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
129/4/372    most recent
ncm444v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Serna, A.
Right arrow Articles by Canteras, M.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Serna, A.
Right arrow Articles by Canteras, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Biological dosimetry and Bayesian analysis of chromosomal damage in thyroid cancer patients

Alfredo Serna1, Miguel Alcaraz2,*, Jose Luis Navarro3, Cristina Acevedo4, Vicente Vicente5 and Manuel Canteras6

1 Medical Physics and Radiation Protection, Hospital Virgen de la Arrixaca, 30120 El Palmar, Murcia, Spain
2 Department of Radiology and Physical Medicine, Faculty of Medicine, University of Murcia, 30100Espinardo, Murcia, Spain
3 Department of Nuclear Medicine, Hospital Virgen de la Arrixaca, 30120El Palmar, Murcia, Spain
4 Clinical Analysis Services, Hospital Virgen de la Arrixaca, 30120 El Palmar, Murcia, Spain
5 Department of Pathology, Faculty of Medicine, University of Murcia, 30100 Espinardo, Murcia, Spain
6 Department of Biostatistics, Faculty of Medicine, University of Murcia, 30100 Espinardo, Murcia, Spain

* Corresponding author: mab{at}um.es

Received May 21, 2007, amended August 28, 2007, accepted September 3, 2007

Chromosomal damage was investigated in lymphocytes of thyroid cancer patients after radioiodine treatment. An assay on micronuclei (MN) in binucleated cells was performed in blood samples of 25 patients 3 d after 131I (3.7 GBq) was given. Statistical analysis does not show overdispersion of the MN distribution, thus considering the exposure to blood as being homogeneous (p < 0.05). A dose-protraction factor (G) of 0.1 was considered into the calculation of the blood dose to take into account the effect of the duration of exposure. The total MN count is a sum of the background distribution and the Poisson distribution induced by radiation exposure. A Bayesian approach was used to avoid inconsistencies when the total count was close to or lower than the background level. Estimated blood dose after 3 d of exposure was 0.73 Gy (0.197 mGy/MBq). The usefulness of the Bayesian method in analysing chromosomal damage when the count is low has been determined.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.