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Radiation Protection Dosimetry Advance Access originally published online on June 6, 2007
Radiation Protection Dosimetry 2007 127(1-4):440-443; doi:10.1093/rpd/ncm297
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© The Author 2007. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Assessment of contributors to radiation dose following intakes of rapidly excreted [14C]-compounds

David M. Taylor*

School of Chemistry, Cardiff University, Cardiff CF10 3TB, UK

* Corresponding author: davtay{at}btinternet.com

The International Commission on Radiological Protection default biokinetic model for the assessment of radiation dose received following intakes of unspecified [14C]-compounds (DCM) appears to overestimate the radiation doses delivered by many [14C]-compounds. The DCM does not specify the route of elimination and this review of the biokinetic data for four [14C]-compounds, [14C]sevelamer, [14C]colestipol, [14C]levetiracetam and [14C]ifetroban, that are rapidly lost from the human body via different excretory pathways, indicates that the excretory pathway is the critical determinant for both the individual tissue doses and the effective dose. If there is significant faecal excretion the DCM does not overestimate the effective dose.


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