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Radiation Protection Dosimetry Advance Access originally published online on June 11, 2007
Radiation Protection Dosimetry 2007 127(1-4):350-355; doi:10.1093/rpd/ncm288
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© The Author 2007. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

MEDOR, a didactic tool to support interpretation of bioassay data after internal contamination by actinides

A. Mièle1, N. Blanchin1, P. Raynaud2, B. Quesne3, J. M. Giraud4, R. Fottorino5, P. Bérard6, E. Ansoborlo7, D. Franck8, E. Blanchardon8, C. Challeton-de Vathaire8, L. Lebaron-Jacobs9, J. L. Poncy10, J. Piechowski4 and P. Fritsch10,*

1 Service médical du travail, CEA Cadarache, 13108 Saint Paul lez Durance, France
2 Service de santé au travail, COGEMA Marcoule, 30207 Bagnols sur Cèze, France
3 COGEMA-AREVA, BP 4, 78141 Vélizy, France
4 CEA, 31 rue de la Fédération, 75752 Paris Cedex 15, France
5 Laboratoire d'analyses de biologie médicale, CEA Cadarache, 13108 Saint Paul lez Durance, France
6 Laboratoire d'Analyses BioMédicales, DSM, CEA Saclay, 91191 Gif sur Yvette, France
7 CETAMA DRCP/DEN/CEA VALRHO Marcoule, BP 17171, 30207 Bagnols sur Cèze, France
8 Laboratoire d'évaluation de la dose interne, IRSN, BP 17, 92262 Fontenay-aux-Roses Cedex, France
9 CARMIN, CEA/DSV, BP 6, 92262 Fontenay-aux-Roses Cedex, France
10 Laboratoire de Radiotoxicologie, SRCA/DRR/DSV/CEA, BP 12, 91680 Bruyères le Châtel, France

* Corresponding author: paul.fritsch{at}cea.fr

A didactic software, MEthodes DOsimètriques de REférence (MEDOR), is being developed to provide help in the interpretation of biological data. Its main purpose is to evaluate the pertinence of the application of different models. This paper describes its first version that is focused on inhalation exposure to actinide aerosols. With this tool, sensitivity analysis on different parameters of the ICRP models can be easily done for aerosol deposition, in terms of activity and particle number, actinide biokinetics and doses. The user can analyse different inhalation cases showing either that dose per unit intake cannot be applied if the aerosol contains a low number of particles or that an inhibition of the late pulmonary clearance by particle transport can occur which contributes to a 3–4 fold increase in effective dose as compared with application of default parameters. This underlines the need to estimate systematically the number of deposited particles, as well as to do chest monitoring as long as possible.


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