Skip Navigation

Radiation Protection Dosimetry 2007 124(2):115-123; doi:10.1093/rpd/ncm137
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (1)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Deperas, J.
Right arrow Articles by Wojcik, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Deperas, J.
Right arrow Articles by Wojcik, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

CABAS: a freely available PC program for fitting calibration curves in chromosome aberration dosimetry

Joanna Deperas1,2, Marta Szluinska3, Marta Deperas-Kaminska2,4, Alan Edwards3, David Lloyd3, Carita Lindholm5, Horst Romm6, Laurence Roy7, Raymond Moss8, Josselin Morand8 and Andrzej Wojcik1,4,8,*

1 Department of Radiation Biology and Health Protection, Institute of Nuclear Chemistry and Technology, ul. Dorodna 16, 03-195 Warszawa, Poland
2 Joint Institute for Nuclear Research, Dubna, Russia
3 Health Protection Agency, Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot, UK
4 Department of Radiation Biology and Immunology, Swietokrzyska Academy, Kielce, Poland
5 STUK – Radiation and Nuclear Safety Authority, Helsinki, Finland
6 Institut für Strahlenhygiene, Bundesamt für Strahlenschutz, Neuherberg, Germany
7 Département de Protection de la santé de l'Homme, Institut de Radioprotection et de Sûreté Nucléaire, Fontenay-aux-Roses Cedex, France
8 Institute for Energy – JRC European Commission, Postbus 2, 1755 ZG Petten, Netherlands

* Corresponding author: awojcik{at}pu.kielce.pl

Received November 17, 2006, amended January 8, 2007, accepted January 14, 2007

The aim of biological dosimetry is to estimate the dose and the associated uncertainty to which an accident victim was exposed. This process requires the use of the maximum-likelihood method for fitting a calibration curve, a procedure that is not implemented in most statistical computer programs. Several laboratories have produced their own programs, but these are frequently not user-friendly and not available to outside users. We developed a software for fitting a linear-quadratic dose–response relationship by the method of maximum-likelihood and for estimating a dose from the number of aberrations observed. The program called as CABAS consists of the main curve-fitting and dose estimating module and modules for calculating the dose in cases of partial body exposure, for estimating the minimum number of cells necessary to detect a given dose of radiation and for calculating the dose in the case of a protracted exposure. The program is freely available at http://www.pu.kielce.pl/ibiol/cabas.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Br. J. Radiol.Home page
Q Liu, J Cao, Z Q Wang, Y S Bai, Y M Lu, Q L Huang, W Z Zhao, J Li, L P Jiang, W S Tang, et al.
Dose estimation by chromosome aberration analysis and micronucleus assays in victims accidentally exposed to 60Co radiation
Br. J. Radiol., December 1, 2009; 82(984): 1027 - 1032.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.