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Radiation Protection Dosimetry Advance Access originally published online on November 28, 2006
Radiation Protection Dosimetry 2006 122(1-4):72-79; doi:10.1093/rpd/ncl441
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

INVITED PAPER

Auger electrons—a nanoprobe for structural, molecular and cellular processes

H. Nikjoo1,2,*, P. Girard2, D. E. Charlton3, K. G. Hofer4 and C. A Laughton2

1 USRA, NASA Johnson Space Center, Houston, TX 77058, USA
2 School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK
3 Physics Department, Concordia University, Montreal, Canada
4 Department of Biological Science, Florida State University, Tallahassee, FL, USA

* Corresponding author: Hooshang.nikjoo{at}jsc.nasa.gov


  Abstract

This paper provides a brief review of recently published work on biophysical and biological aspects of Auger processes. Three specific questions have been considered. (1) Does charge neutralisation contribute to molecular damage such as DNA strand breaks? (2) How many DNA double strand breaks are produced by a single decay of DNA bound 125I? (3) What is the correlation between number of {gamma}H2AX foci and number of double strand breaks (DSB)? The paper also gives preliminary reports on two new calculations: (a) calculation of the spectrum of Auger electrons released during decay of 124I and (b) the use of Auger electrons in the decay of 125I as a probing agent of novel DNA structures.


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