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Radiation Protection Dosimetry Advance Access originally published online on December 12, 2006
Radiation Protection Dosimetry 2006 122(1-4):335-339; doi:10.1093/rpd/ncl463
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Mechanistic modelling of genetic and epigenetic events in radiation carcinogenesis

AndreevS. G. *, EidelmanY. A. , Salnikov I. V. and KhvostunovI. K.

Institute of Biochemical Physics, Kosygin Street. 4, 119991, Moscow, Russia

* Corresponding author: andreev_sg{at}mail.ru


  Abstract

Methodological problems arise on the way of radiation carcinogenesis modelling with the incorporation of radiobiological and cancer biology mechanistic data. The results of biophysical modelling of different endpoints [DNA DSB induction, repair, chromosome aberrations (CA) and cell proliferation] are presented and applied to the analysis of RBE–LET relationships for radiation-induced neoplastic transformation (RINT) of C3H/10T1/2 cells in culture. Predicted values for some endpoints correlate well with the data. It is concluded that slowly repaired DSB clusters, as well as some kind of CA, may be initiating events for RINT. As an alternative interpretation, it is possible that DNA damage can induce RINT indirectly via epigenetic process. A hypothetical epigenetic pathway for RINT is discussed.


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