Skip Navigation


Radiation Protection Dosimetry Advance Access originally published online on January 17, 2007
Radiation Protection Dosimetry 2006 122(1-4):188-194; doi:10.1093/rpd/ncl476
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
122/1-4/188    most recent
ncl476v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Takakura, K.
Right arrow Articles by Fujibayashi, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Takakura, K.
Right arrow Articles by Fujibayashi, Y.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Enhancement of chromosomal aberrations in tumor cells with a non-labeled Cu–PTSM and irradiation with Cu K-shell monochromatic X rays

Kaoru Takakura1,*, Satoshi Yaguchi1, Yuichi Kanansugi1, Katsumi Kobayashi2, Ryuichi Okayasu3 and Yasuhisa Fujibayashi4

1 Physics Department, Division of Natural Sciences, International Christian University, Mitaka-shi, Tokyo 181-8585, Japan
2 Institute of Material Science, High Energy Accelerator Organization, Tsukuba-shi, Ibaraki 305-0801, Japan
3 Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba-shi, Chiba 263-8555, Japan
4 Biomedical Imaging Research Center, Fukui University, Matsuoka, Fukui 910-1193, Japan

* Corresponding author: kaoru{at}icu.ac.jp


  Abstract

This study aims to clarify the enhancement effect on chromosomal aberrations via selective energy absorption by Cu atoms in cultured bone cancer cells with non-labelled Cu–pyruvaldehyde-bis(N4-methylsemicarbazone) (Cu–PTSM) and monochromatic X rays. The X rays having the energy of the Cu K-shell absorption edge arising from synchrotron radiation (KEK-PF) was used as radiation source. Cu–PTSM labelled with copper radionuclides has been developed for medical imaging using positron emission tomography (PET). Evidence clearly showed that the absorption of X rays in the Cu K-shell caused this enhancement. After cells were treated with 1000 nM Cu–PTSM, the enhancement ratio of the initial yield of isochromatid breaks caused by CuK-H X-ray irradiation to that by 200 kVp X rays was ~2.8. About 5.6 times of the remaining isochromatid breaks were observed at 4 h in Cu–PTSM treated samples irradiated with CuK-H X rays comparing to that with 200 kVp X rays. In this study, uniqueness in physical property such as Cu atom K-shell ionisation was applied for the enhancement of biological effects in cancer cells.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.