Radiation Protection Dosimetry Advance Access originally published online on December 4, 2006
Radiation Protection Dosimetry 2006 122(1-4):180-184; doi:10.1093/rpd/ncl457
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Neoplastic transformation of a human hybrid cell line by alpha particles in relation to mammography X rays
University of Goettingen, Center of Radiology, Department of Nuclear Medicine, Von-Siebold-Strasse 3, D-37075 Goettingen, Germany
* Corresponding author: dfrank{at}med.uni-goettingen.de
| Abstract |
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The hybrid cell line CGL1 is the only cell line which allows quantitation of neoplastic transformation in human cells. Hybrid cells were exposed to 3.4 MeV alpha particles or to mammography X rays (29 kVp) and both survival and neoplastic cell transformation were assayed. For comparison, previously published data obtained with 200 kVp X rays are also included. Alpha particles were significantly more efficient than 29 kVp X rays in cell killing. Surprisingly, the efficiency of mammography X rays for the induction of neoplastic cell transformation was close to that observed for alpha particles.