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Radiation Protection Dosimetry Advance Access originally published online on March 10, 2007
Radiation Protection Dosimetry 2006 122(1-4):124-127; doi:10.1093/rpd/ncl495
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

INVITED PAPER

Radiation-induced DNA damage responses

Penny Jeggo1,* and Markus Löbrich2

1 GDSC University of Sussex, Sussex BN1 9RQ, UK
2 Fachrichtung Biophysik,Universität des Saarlandes, D-66421 Homburg/Saar, Germany

* Corresponding author: p.a.jeggo{at}sussex.ac.uk


  Abstract

The amazing feature of ionising radiation (IR) as a DNA damaging agent is the range of lesions it induces. Such lesions include base damage, single strand breaks (SSBs), double strand breaks (DSBs) of varying complexity and DNA cross links. A range of DNA damage response mechanisms operate to help maintain genomic stability in the face of such damage. Such mechanisms include pathways of DNA repair and signal transduction mechanisms. Increasing evidence suggests that these pathways operate co-operatively. In addition, the relative impact of one mechanism over another most probably depends upon the cell cycle phase and tissue type. Here, the distinct damage response pathways are reviewed and the current understanding of the interplay between them is considered. Since DNA DSBs are the major lethal lesion induced by IR, the focus lies in the mechanisms responding to direct or indirectly induced DSBs.


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