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Radiation Protection Dosimetry Advance Access originally published online on May 17, 2005
Radiation Protection Dosimetry 2005 114(4):509-513; doi:10.1093/rpd/nci301
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© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Effect of calcium trisodium DTPA in rats with puncture wound contaminated by 90Y-chloride

N. Watanabe*, S. Tanada and Y. Sasaki

Department of Medical Imaging, National Institute of Radiological Sciences, Chiba 263-8555, Japan

* Corresponding author: N.Watanabe{at}iaea.org

Received March 4, 2005, accepted April 24, 2005

The efficacy of diethylenetriaminepentaacetate calcium trisodium (CaNa3DTPA) in a dose of 34.7 µmol kg–1 as a function of its route of administration was investigated in rats with a puncture wound contaminated by 90Y-chloride at a concentration of 2.55 MBq kg–1. Approximately 60% of 90Y-chloride at a puncture wound was absorbed into the body of rats over 72 h post-puncture and radioactivity in femoral bone increased during the timed-release of 90Y. Intravenous administration of CaNa3DTPA (systemic treatment) at 15 min post-puncture reduced 90Y at a puncture wound and in bone up to 75.6 and 84.3% of controls, respectively. Direct infiltration of CaNa3DTPA into a puncture wound site (local treatment) at 15 min post-puncture diminished radioactivity at the puncture wound and in bone up to 34.9 and 52.5% of controls, respectively. Thus, prompt local treatment may be effective for removing 90Y from a puncture wound and minimising 90Y-distribution to bone compared with systemic treatment.


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