Skip Navigation


Radiation Protection Dosimetry Advance Access originally published online on November 30, 2004
Radiation Protection Dosimetry 2005 113(2):152-161; doi:10.1093/rpd/nch435
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
113/2/152    most recent
nch435v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (8)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Sevan'kaev, A. V.
Right arrow Articles by Barquinero, J. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sevan'kaev, A. V.
Right arrow Articles by Barquinero, J. F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2004. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

A cytogenetic follow-up of some highly irradiated victims of the Chernobyl accident

A. V. Sevan'kaev1, D. C. Lloyd2,*, A. A. Edwards2, I. K. Khvostunov1, G. F. Mikhailova1, E. V. Golub1, N. N. Shepel1, N. M. Nadejina3, I. A. Galstian3, V. Yu. Nugis3, L. Barrios4, M. R. Caballin4 and J. F. Barquinero4

1 Medical Radiological Research Centre of RAMS, Koroliov St. 4, Obninsk, Kaluga Region, 249036, Russia
2 National Radiological Protection Board, Chilton, Didcot, Oxon, OX11 0RQ, UK
3 State Scientific Centre Institute of Biophysics, Zhivopisnaya 46, 123182, Moscow, Russia
4 Autonomous University of Barcelona, 08193 Bellaterra (Barcelona), Spain

* Corresponding author: david.lloyd{at}nrpb.org

Received July 19, 2004, amended October 27, 2004, accepted November 8, 2004

A follow-up of 10 highly irradiated men, mostly reactor crew, from the Chernobyl accident is described. Their pre-accident medical conditions and relevant medical status approximately 10–13 y later are listed. A comparison is made between estimates of their average whole-body penetrating radiation doses derived from several biological parameters. First estimates were based on their presenting severity of prodromal sickness, early changes in blood cell counts and dicentric chromosome aberrations in lymphocytes. In three cases ESR measurements on tooth enamel were also made. Retrospective dosimetry using FISH translocations was attempted 10–13 y later. This showed good agreement for those patients with the lower earlier dose estimates, up to about 3 Gy. For the others, extending up to about 12 Gy, the translocations indicated lower values, suggesting that in these cases translocations had somewhat declined. Repeated chromosomal examinations during the follow-up period showed an expected decline in dicentric frequencies. The pattern of decline was bi-phasic with a more rapid first phase, with a half-life of ~4 months followed by a slower decline with half-lives around 2–4 y. The rapid phase persisted for a longer time in those patients who had received the highest doses. 10–13 y later dicentric levels were still above normal background, but well below the translocation frequencies.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.